Panorama Non-Invasive Prenatal Test

Panorama Non-Invasive Prenatal Test £450

Panorama: Next-generation NIPT. Panorama is a market-leading non-invasive prenatal screening test (NIPT) that reveals your baby’s risk for genetic disorders as early as 9 weeks. Panorama analyzes baby’s (placental) DNA through a simple blood draw from the mother’s arm. 

If you choose PANORAMA Non-Invasive Prenatal Testing it includes:

 an early viability or growth scan (scan selection depends on your stage in pregnancy)

 the opportunity to discuss your results with an experienced Consultant consultation with Innermost Healthcare private healthcare company,  Founded and led by Dr Robert Bryan Beattie MD FRCOG (a current Consultant in Obstetrics, Fetal & Maternal Medicine in the NHS) who provide the very latest technologies, services and expert advice.

 Information about your options and support with your choices

According to the  International Society for Prenatal Diagnosis (ISPD) and American College of Medical Genetics and Genomics (ACMG) support offering NIPT as a first-line screen., non-invasive prenatal testing (like ) is appropriate as a Primary Screening Test for pregnant women of all ages. Down Syndrome and certain other chromosomal conditions occur more frequently in babies born to mothers over 35 years old. Other conditions for which NIPT  screens – such as microdeletion syndromes – occur with the same frequency in babies, regardless of the mother’s age.

Https://www.natera.com/panorama-test 

To Contact us for more information to know about these blood test call  📞 01138301371  to speak with the Healthcare Professional  and we can also provide 

Two levels of analysis: 

Standard Panorama Non-Invasive Prenatal Test  - £450.00

  • Panorama is a market-leading noninvasive prenatal screening test (NIPT) that reveals your baby’s risk for genetic disorders as early as nine weeks. Panorama analyzes baby's (placental) DNA through a simple blood draw from the mother’s arm.
  • Screens for T21, T18 and T13 , 22q11.2 deletion syndrome (DiGeorge), sex chromosome. Available even for Twin pregnancies
  • Pre-test  and Post-test counselling if required.
  • Blood samples are collected by the courier on the same day 
  • Results available 7-10 days

Panorama Non-Invasive Prenatal Test including 5 micro-deletions  £500

  • Panorama + 5 microdeletions screens for T21, T18, T13 , Sex chromosome, Triploidy, Monosomy X, Di George Syndrome, 1p36 deletion syndrome, Angelman syndrome, Prader-Willi syndrome and Cri-du-chat syndrome.
  • An ultrasound is included.
  • Blood samples are collected by the courier on the same day 
  • Pre-test and Post-test counselling if required.
  • Panorama extended microdeletion panel: add 1p36, Angelman, Cri-du-chat, Prader-Willi
  • Optional fetal sex, with 100% accuracy 
  • Applicable to twin pregnancies, egg donors, surrogate pregnancies.
  • We will detect vanishing twins (first source of false positives with other tests), report individual fetal fractions, give individual fetal sex, and report chorionicity at 9 weeks. 

What do about my Regular NHS 12 weeks scan and NT measurements scans?

If you are having NIPT Test or you have got negative or Low-risk result on the Non-Invasive Prenatal  Test you should still attend and not miss your regular 12 week NHS  scan and the NT measurements.

What Panorama Screens For

Panorama is the only non-invasive prenatal screening test that distinguishes between fetal and maternal cell-free DNA thanks to SNP-based sequencing and Natera’s proprietary algorithm. Using advanced bioinformatics techniques, Panorama screens for a broad panel of chromosomal conditions, including:

Chromosome Abnormalities

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Triploidy

Sex Chromosome Abnormalities

  • Monosomy X (Turner syndrome)
  • Klinefelter syndrome
  • Triple X syndrome
  • XYY syndrome

Microdeletions

  • 2 deletion syndrome
  • 1p36 deletion syndrome
  • Prader Willi syndrome
  • Angelman syndrome
  • Cri-du-chat syndrome
  • Gender of the Baby (optional)

In Twin Pregnancies

Non-identical or fraternal twins

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Gender of each twin (optional)

If our screening finds that your twins are identical, Panorama can additionally screen for:

  • Monosomy X (Turner syndrome)
  • Sex chromosome trisomies
  • 2 deletion syndrome (optional)

Egg Donor or Surrogate Pregnancies

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Gender (optional)

How accurate is the test?

Clinical studies have shown exceptional accuracy for detecting fetal trisomy.

What does the DETECTION RATE mean?

The detection rate or sensitivity is the ability to correctly identify a truly high risk case as high risk. For example, in a group of Trisomy 21 cases, Panorama will correctly identify more than 99% of those cases.

What is SPECIFICITY?

This is the ability to correctly identify an unaffected case as low risk.

What is the POSITIVE PREDICTIVE VALUE (PPV)?

This is the likelihood that the result says high risk and the fetus is actually affected. For example, when the Panorama Test shows a high risk result, there is a 91% chance that the fetus is affected by Trisomy 21. In other words, 9% of the time, you may get a high risk result when the fetus is not affected by Trisomy 21.  For Trisomy 13, the PPV is however only 38% (see the information in the ‘learn more’ section).

Follow-up was gathered from Panorama cases submitted for testing between 2014 and 2017

- The cohort included a total of 1,035,844 test results, of which, 13,231 (1.3%) were high risk. 

- Using the most conservative definition for confirmation, our observed PPVs were as follows:

  •        T21 = 94.7%
  •        T18 = 91.3%
  •        T13 = 67.8%
  •        Monosomy X = 77.5%. 
  •        Overall = 90.3%

What is the NEGATIVE PREDICTIVE VALUE (NPV)?

This is the likelihood that the result says low risk and the fetus is truly not affected.

What does a HIGH RISK result mean?

A HIGH RISK result is indicative of a high risk for a condition. The actual risk of an affected fetus depends on the condition being screened for and is the PPV (see the table in the ‘learn more’ section for detailed information on each condition). After the test, the number of women required to have a CVS or an amniocentesis is less than 1%. It is important to note that if the test results show there is a HIGH risk that the fetus has trisomy 21, 18 or 13 it does not mean that the fetus definitely has one of these defects, although it is highly likely. For this reason, in the event of a high risk (or positive) result, follow-up testing by an invasive procedure is recommended.

What does a LOW RISK result mean?

If the test results show that there is a LOW RISK that the fetus has a condition, it is unlikely that the fetus has one of these defects. The actual risk depends on the condition being screened for and is the NPV (see the table in the ‘learn more’ section for detailed information on each condition). However there is a very small risk that not all trisomy fetuses will be detected. All results should be interpreted by a clinician in the context of clinical and familial data: patients should continue with their usual scan appointments following testing.

How long will it take to get results?

Typically within 2 weeks but occasionally (3% of tests which are done) if there is not enough fetal DNA in the original blood sample then a repeat blood test may be required within a week of the original test at no extra cost.

Are there any risks to the pregnancy from the Panorama Test?

No. The testing is non-invasive: it involves taking a blood sample from the mother. The pregnancy is not put at risk of miscarriage, or from other adverse outcomes that are associated with invasive testing procedures such as CVS or amniocentesis

What do about my Regular NHS 12 weeks scan and NT measurements scans?

If you are having NIPT Test or you have got negative or Low-risk result on the Non-Invasive Prenatal  Test you should still attend and not miss your regular 12 week NHS  scan and the NT measurements.

What if the sample fails?

Statistically there is a 3 to 4% failure rate that there is not enough cell free DNA in the blood sample to analyse. In this event a new sample will need to be taken again at no extra cost.

What if I have a high BMI?

The relative proportion of cell-free fetal DNA is reduced in women with a high BMI as they have more of their own cell-free DNA circulating in their blood. This may increase the chance of getting an inconclusive result.

  • Genetic counselling is available to all clients. Contact us about this service and we will put you in touch with someone who is trained to talk you through your result, whatever the outcome.

 Please note

  • We will require details of your GP / Health Care Professional, which may be requested prior to or at the time of the scan.
  • This scan requires access to the area of interest, therefore it is recommended to wear loose clothing to facilitate this process.
  • Blood results require interpretation and All results should be shared with your regular healthcare professional / GP / Fertility specialist.
  • All of our first line ultrasound scans & health Blood tests are optional. You must be at least 16 years old and you should have no existing medical condition or treatment pending that relates to the scan/blood test  you are booking. If you are in any doubt about having any type of test, you should consult your GP.
  • Genetic counsellors  : Patients have access to our genetic counsellors (pre and post-test). Here is a link to a website allowing you to book online a free 15 minutes call to discuss a result with a board-certified genetic counsellor: www.naterasession.com

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